Saving data from DataGridView to Sql Database

I am using the  code below to populate the ComboBox control and the Data GridView Control

Private Sub ComboBox1_SelectedIndexChanged(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles ComboBox1.SelectedIndexChanged
        ' Get the Parameter object and Set value
        With (SqlDataAdapter1.SelectCommand.Parameters)
            .Item("@SupplierParam").Value = _
             ComboBox1.SelectedValue
        End With

        ' Clear the dataset
        DsRma1.Clear()
        ' Load the dataset using the parameter value
        SqlDataAdapter1.Fill(DsRma1, "RmaDetails")

    End Sub

the data grid has tow rows with no data , I want to input data into these two rows and then save the whole data back to the  SQL database, see image

Do i need to do an Inset command , or drop a Binder navigator onto the form and then click the save button

any help would apreacited

thanks