Failure of second call to dll by the reflection

I have  a method "Start" in a dll which is invoked via reflection using the following code:

StandAloneInstance.GetMethod("Start", new Type[] { }).Invoke(new object(), null))

here StandAloneInstance is an object of   System.Type 

Whenever I run the code for the first time all runs perfectly and when I invoke the same function without exiting the application it goes in an infinity wait.

However if I stop the application and rerun it all is well again.

While in debugging mode the debugger hangs after the execution of the above line.

Please guide to crack this issue.